Quickly heal wounds in HIV. Features of the oral cavity in HIV infection

Solution for outdoor use.

Basic physico-chemical properties: Colorless transparent viscous liquid.

Pharmacological group

Antifungal drugs for local applications. The derivatives of imidazole and triazole.

Code ATH D01A C01.

Pharmacological properties

Pharmacological.

Clotrimazole is a derivative of imidazole, antifungal agent of a wide range of action. The mechanism of its action consists in braking the synthesis of ergosterol, which is necessary for the construction of the mushroom cell membrane, which leads to a violation of its permeability and further destruction of the cell. In addition, Clotrimazole suppresses the activity of peroxidase, which further facilitates the accumulation of hydrogen peroxide fungus. The concentration of hydrogen peroxide rises to a toxic level, which leads to further destruction of the cell.

Clotrimazole has a wide range of action: effective against dermatophytes, yeast fungi; Exhibits an antibacterial effect against eritresses, staphylococcular causative agents ( Staphylococcus SPP.) and streptococci ( Streptococcus SPP.)

Pharmacokinetics.

When applied to the skin penetrates the horny layer of the skin and accumulates there. With external use through the skin, a slight amount of the drug is absorbed. It is practically not absorbed into systemic blood flow.

Indications

Fungal diseases of the skin and mucous membrane caused by pathogens sensitive to clotrimazole.

Multicolored deprived, erytrazm.

Contraindications

Increased sensitivity to clotrimazole or other components of the drug. Increased sensitivity to other imidazole.

Interaction with other medicines and other types of interactions

Clotrimazole suppresses the effect of other antifungal drugs for external use, in particular amphotericin, nistatin and natamicin.

Clotrimazole antimicrobial effect enhances high concentrations of hydroxybenzoic acid propyl ether.

Dexamethasone in high doses inhibits the antifungal effect of Clotrimazole.

Features of application

The drug is intended for use only in dermatological practice.

It is prohibited to use the drug in ophthalmological practice. Avoid contact with the preparation with eyes. Do not apply in the eye area.

Do not comb the affected parts of the body, which are squealing, as this leads to the spread of the disease.

There are reports of the reaction of cross-hypersensitivity, so in the case of an allergic reaction to any antifungal agent from the group of derivatives of imidazole, it should be borne in mind the possibility of such a reaction to another drug of this group. When an allergic reaction appears, clotrimazole treatment should be discontinued.

The use of the genital solution (external genital organs and the crotch in women or the head of the penis and the extreme flesh in men) can reduce the efficiency and safety of the use of latex products, such as a condom and a diaphragm. The specified effect is temporary and can only occur during treatment.

Application during pregnancy or breastfeeding

Clinical studies on the influence of Clotrimazole on fertility in women were not carried out, but animal studies did not reveal the effects of Clotrimazole on fertility.

The number of studies using clotrimazole during pregnancy is limited. Studies on animals did not reveal direct or indirect harmful effects from the point of view of reproductive toxicity. As a preventive measure, it is advisable to avoid the use of clotrimazole during the first trimester of pregnancy.

During the treatment of Clotrimazole should stop breastfeeding.

The ability to influence the reaction rate when managing motor vehicles or other mechanisms

Does not affect.

Method of application and dose

Adults apply the candidium solution on the affected areas 2-3 times a day before the disappearance of the symptoms of the disease. The disappearance of symptoms is expected after the course of treatment during this period:

dermatomikosis - 3-4 weeks;
Erytrazm - 2-4 weeks;
multicolored deprived - 1-3 weeks.

After the disappearance of subjective symptoms, to ensure the effectiveness of treatment, depending on the disease, it is necessary to continue the use of Candida, the solution, for another 2 weeks.

Children

The experience of applying a candidium solution in children is absent, so this category of patients should not be applied.

Overdose

There is no risk of acute intoxication, since it is unlikely that an overdose is possible after a single vaginal dose or application on the skin (use in large areas of the skin under conditions that contribute to increased suction), as well as after accidental oral administration. Specific antidote does not exist.

In case of accidental oral administration, it is rarely necessary to carry out the stomach wash if the dose of threatening life was applied during the previous hour or if there are visible overdose symptoms (for example, dizziness, nausea or vomiting). Stomach washing should only be carried out in cases where there is a proper protection of the respiratory tract.

Candid - Clotrimazole-based drug, which has fungistatic and fungicidal properties used to treat fungal infections. In small doses, it suppresses the development and reproduction of the pathogen, and in large - destroys the fungus, disturbing the synthesis of the substances necessary for the structure of its cells.

Properties, composition and shape of the drug Candid

The active ingredient of the drug Candid is effectively in the struggle with many types of fungi, causing lesions of the skin, nails and mucous membranes. Clotrimazole with local application penetrates the tissue and accumulates in them at maximum concentration, almost not absorbing blood. The drug is able to influence the production of ergosterol necessary for cell membranes of the pathogen. With the lack of this substance, the walls of the cells are destroyed, the fungus cannot multiply and dies.

Different drug forms of the drug contain excipients that facilitate its use. Usually for the treatment of fungus in children, candidy is used in the following forms:

candid Cream (ointment), 1% - white substance in aluminum tubes of 20 g;
solution (drops) for local applications, 1% - viscous transparent liquid for processing the mucosa of the mouth during the thrush, the bottle-dropper 15 ml;
solution for outdoor use, 1% - polyethylene bottle 20 ml;
plipping 10 mg / g - white powder for treating fungus, plastic bottle 30 g

There are also other dosage forms Candida: gel, vaginal tablets, etc. Based on the testimony and concentration of the active substance, they are more suitable for the treatment of fungal infections in adults.

Indications for use

In pediatrics, including newborns, candidis is used to treat the cavity of the oral cavity (thrush), stomatitis, skin candidides and other fungal infections (we recommend reading :). The drug is prescribed to children of any age with lesions of the skin, nails, hairproof or mucous membranes caused by the activity of fungal flora:

candidiasis of the oral cavity (thrush) - foci of white plaque on the mucous membrane;
candadose stomatite - inflammation of the mucous membrane caused by yeast, mold and other types of fungi, as well as a decrease in immunity;
diaper dermatitis - reproduction fungus on the skin due to insufficient baby hygiene or non-compliance with temperature conditions indoors;
some kinds of losing, mikosah skin or nails;
other lesions of the skin or mucous membranes, provoked by uncontrolled reproduction of fungal flora.

Candid is effective for the treatment of thrush in infants

Instructions for use with dosages by age

There is no restrictions on the age for the drug Candide - according to the testimony, it is prescribed even newborn and infants. However, it is necessary to clearly comply with the dosage prescribed by the doctor or the instructions for a particular dosage form, and in no case apply the drug on its own, without the purpose of a specialist.

Solution for processing stomatitis and thrush

The thrush and stomatitis, provoked by mushrooms, often develop in infants against the background that has not yet formed immunity. In the oral cavity there are foci of white plaque, while trying to remove the mucous, begins to bleed (more in the article :). Taking the smear, the doctor will determine its origin and will diagnose. In the absence of treatment at this stage, the mucosa is inflamed, stomatitis develops.

When candidium stomatitis, candides for newborns are prescribed in the form of a solution for local use in a plastic bottle-dropper. Dose for children, incl. The newborns are 5-10 drops (0.25-0.5 ml) of the solution - it is applied on a cotton wand or wrapped marley finger, after which the foci of white plaque is lubricated in the oral cavity 3-4 times a day.

It is impossible to stop treatment at the first signs of improving the state, it is necessary to continue the use of the drug until the symptoms are completely eliminated.

If the child is on breastfeeding, the mother needs to be treated with a solution not only the mouth of the baby, but also its nipples for preventing repeated infection.

Cream and solution for outdoor use

With fungal lesions of the skin or nails, degrating, mikosakhs of unspecified origin, candidy is used in the form of a cream or ointment according to the following scheme:

wash the affected skin with soap with neutral acidity;
thoroughly dry the skin;
apply a thin layer of cream and carefully launched it into the fabric.

The procedure is performed 2-3 times a day after eating (feeding), the duration of the course of treatment depends on the specific diagnosis and age of the patient. In some cases, the doctor recommends continuing treatment a few more days after the complete disappearance of symptoms.

In the presence of these same diseases, it is possible to use a 1 percent solution for outdoor use. For children under 2-3 years, it is often prescribed by this dosage form, since there are fewer auxiliary substances in the solution, which means a smaller probability of adverse reactions. The solution is used by the same scheme as the cream: applied to washed with soap and dried skin sections 2 or 3 times a day.

Skin powder

For the treatment of fungal infections that are localized on the skin of the child, Candid powder is used. Before applying the drug, the affected place must be washed and dried, then spray the powder from the bottle to the localization site of the fungus. The procedure is carried out 2-3 times a day, the duration of treatment is usually about 14 days, but the doctor can change this period depending on the condition and age of the child. With a large area of \u200b\u200bthe defeat or with the aim of preventing re-infection, it is sometimes recommended to apply a little powder on clothes or baby diaper.

Contraindications and possible adverse reactions

Candid in the treatment of children, as a rule, is moved well. The only absolute contraindication can be considered the individual sensitivity to the clotrimazole or any of the auxiliary substances. Candid does not apply on damaged skin sites (ulcers, scratches, etc.) and in the eye area.

Side effects may occur in the form of a local allergic reaction - itching, burning or redness of the skin or mucous membranes, sometimes nausea is observed. In this case, the treatment with candides stop.

In the treatment of skin infections, an occlusal dressings cannot be used - the active substance penetrates into the blood and has a negative effect on the children's body. In particular, there is an oppression of the function of the adrenal cortex in children.

Cost and analogs

Candid is released in pharmacies without a recipe. The average cost of different dosage forms:

As analogues, Candida can use any drug, the main component of which is Clotrimazole. When choosing a similar drug, you need to carefully study the instructions and listen to the recommendations of the doctor. The most popular analogues Candida: Kanizon, Rederm, Candiders, Candiben, Antifungal, etc.

A synthetic antifungal medicine of a wide range of activity is candid. Instructions for use indicates that tablets or candles vaginal 500 mg, cream 1%, gel 2%, solution 1% is used to treat fungal lesions of mucous membranes and skin.

Release form and composition

The drug is produced in the following dosage forms:

gel Candid 2%;
powder for use externally 1%;
vaginal tablets (candles) Candid;
the solution for use is local 1%;
application cream outfit 1%;
Candide B6 - Vaginal Tablets 100 mg (Candle Analogue);
Candid b - cream for outdoor use.

Cream is a homogeneous substance of white, contained in the aluminum tube for 20 g. The cream contains the active ingredient of Clotrimazole, as well as the auxiliary components: white vaseline, propylene glycol, emulsion cetomacrologol wax, liquid paraffin, butylhydroxitololool, propyl paragidroxybenzoate, methylpagidroxybenzoate, benzyl alcohol , sodium hydrophosphate, sodium dihydrophosphate dihydrate, purified water.

A solution for local applications, transparent, colorless, has a viscous consistency. The bottle contains 15 g. The candidium solution contains the active component of clotrimazole, as well as glycerol and propylene glycol as additional components.

Vaginal tablets contain a clotrimazole as an active ingredient, as well as additional ingredients: purified talc, starch, magnesium stearate, lactose, silica dioxide, propylparaben, methylpaultsibenzoate, sodium carboxymethyl starch.

Powder for use externally (powder) is contained in a plastic bottle for 30 g. In addition to the box with a preparation.

pharmachologic effect

Tablets, vaginal gel, powder, solution and cream Candid are antifungal drugs widely used in the treatment of various candidal diseases. The active ingredient of this means perfectly penetrates into all layers of skin, destroying the cells of bacteria.

Active ingredient drugs (clotrimazole) detrimental effect on yeast, yeast and fungi (Candida, Torulopsis, Rhodoturola), some strains of Gram-positive and Gram-negative microorganisms (Gardnerella vaginalis, Corynebacterium minutissimum, Bacteroides spp., Staphylococcus spp., Streptococcus spp.) And dermatophyte (Epidermophyton, Trichophyton, Microsporum).

Indications for use

What does Candid help from? The drug is used if the patient has the following diseases or symptoms:

candadose vulvit;
candidose paronyth;
erythracy;
candidose Balanit;
candidosis of skin cover;
mycoses Stop and skin folds;
surface candidiasis that cause yeast, mold and other mushrooms, dermatophytes, as well as a number of other pathogens demonstrating the sensitivity to Clotrimazole;
mycoses, under which the complication of secondary pyoderma is noted;
fungal diaper dermatitis;
candidiasis of the rear pass and outdoor genitals;
fly-shaped deprived, multicolored deprived.

Candidium solution for oral cavity is used in stomatitis of candidal origin.

Vaginal tablets are used to treat genital infections, as well as genital superinfections that are provoked by microorganisms sensitive to Clotrimazole.

Candid is also used to renowned the generic pathways during preparation for childbirth.

Instructions for use

Candid pills vaginal or candles

It is introduced intravaginal, deep, in the "lying on the back" position with a slightly bent feet. 500 mg once (in the evening). The re-course of treatment is possible after the consultation of the doctor. Single introduction 1 Table is recommended for rehanging trips.

Powder

Externally. Powder is applied to the affected skin 3-4 times a day. Improving the state occurs within 3-5 days. For successful treatment, the regular use of the drug is important. The duration of therapy is individual and depends on the severity and localization of the disease.

To achieve complete recovery, it should not be discontinued by the drug immediately after the disappearance of acute symptoms of inflammation or subjective complaints. The duration of therapy should be, on average, about, 4 weeks: with a bowl-shaped delay - 1-3 weeks, with eritresses - 2-4 weeks. With interfallated fungal erosions of the legs, it is recommended to continue therapy for about 2 weeks after the symptoms of the disease.

Cream or gel

The required amount of cream or lotion is applied to a pre-washed and dry affected area of \u200b\u200bskin 2-3 times a day. Treatment should be continued for another 2-4 weeks after the disappearance of clinical symptoms to ensure micrological cure and prevent recurrence. The preparation in the form of lotion is used for large lesions and on the skin of the skin.

The cause of candidial stomatitis or thrush in childhood becomes active reproduction of the Candida's conditionally pathogenic fungus. When a child's immune protection decreases, active reproduction of fungus begins. As a result of vital activity of the colony of fungi on the surface of the mucosa of the mouth, a dense white-colored flare is formed, hiding painful erosion. Quite often in the treatment of children's candidial stomatitis, the child is appointed Candid.

Form of drug and composition

"Candid" is an antifungal agent that is included in the group of derivatives of imidazole. In the pharmacy you can purchase a means in the form of gel, tablets and a solution. It is a solution of the drug and is used in stomatitis.

The aqueous solution is proposed in dropper bottles, 15 ml. According to the consistency, the composition is quite viscous and completely transparent. The active ingredient of the drug is Clotrimazole.

In one millilitress of the drug contains ten milliliters of Clotrimazole.

The auxiliary components are glycerol and propylene glycol.

Indication to the use of the drug "Candid"

The remedy is used to treat the lesions of the mucous membrane in the candidium (fungal) stomatitis, provoked by yeast-like fungi of the genus Candida.

The drug in the shortest possible time copes with the colonies of fungus, overwhelming its development. It is noteworthy that Kandid gives an excellent effect even with a significant weakening of immune protection in a child. That is why the medicine is prescribed in diabetes and immunodeficiency states.

Contraindications to the application of the fund "Candid"

When local use, the drug is practically not absorbed by mucous membranes. That is why the tool can be used without feasible in children of all ages and infants here is no exception.

From the use of the drug, it is necessary to abandon the existing individual intolerance to the child of the component composition "Candid".

With caution, this medicine from stomatitis needs to be used in infancy. Since Clotrimazole is a fairly active substance, then the dose-recommended dose prescribed by the pediatrician is extremely recommended.

"Candid" for the oral cavity for children

The instruction contains the following instructions:

processing needed two to three times during the day;
the duration of treatment is two weeks.

Dosage for adult patients is ten - twenty drops. For the treatment of thrush in children, the dosage is reduced two to three times. But the exact rate of the drug for one processing must select a pediatrician, taking into account the age of the child.

Improving the state of the oral cavity in kids is recorded at about the third - fifth day from the start of treatment. This course does not need to discontinue treatment. To secure the effect therapy, Candid therapy needs to continue to ten full days.

The treatment diagram is as follows:

Before applying means, the oral cavity should be cleaned of white plaque. Here you can use soda solution. For its preparation in a glass of boiled water dissolve the spoon of soda. Then the index finger needs to be wrapped with a sterile bandage and moisten it in the cooked composition. After that, you need to carefully treat the inflamed mucosa.
After that, the affected areas can be treated with Candid tool.

With the thrush in the infants, the soda solution to the soda solution is recommended to be carried out up to five times during the day, regardless of the use of "Candid". Drug treatment can be performed only twice a day - in the morning and in the evening.

Dr. E. O. Komarovsky believes that any medication should be appointed by a qualified specialist. Independent use of medicines, especially at breast age, may cause various complications.

Side effects

As a rule, adverse reactions when using funds in children arise quite rarely. Reviews of mammies practicing treatment with the Candid means are confirmed.

The reaction to the drug can manifest itself in the form:

irritation of mucous after applying means;
feeling of burning;
redness of the mucous
the tool has a sufficiently unpleasant taste and when hitting the throat can provoke a slight gender.

If the child has listed symptoms, the treatment must be canceled.

Summary

The remedy may be part of complex therapy, but it must be remembered that "Candid" cannot be combined with Nystatin preparation, as well as medicines from a group of polyenov preparations.

One of the reasons for education in the oral cavity in the oral cavity is a fungal infection. For treatment, in such cases, drugs are prescribed with an anti-microtic effect of internal and outdoor use. On the antifungal agent Candid used to localize the problem on the mucous membrane, and will be discussed in this article.

Indications for use

The candidate solution is prescribed by patients who have a damage to the mucous membrane of the oral cavity or pharynx as a result of the intensive development of mushrooms of various types (mold, yeast, dermatophytes). The drug is shown to use under candidal stomatitis, developed against the background of immunity reduction.

The composition of the solution

Candide is the active substance of the drug is clotrimazole (1 gr. The solution includes 10 mg of the main substance). The composition includes auxiliary components: glycerol, propylene glycol.

Manufacturer - Glenmark (India).

The mechanism of action is based on the properties of Clotrimazolewhich suppresses the growth of pathogenic fungi by violation of the integrity of cell membranes.

Form release

The drug is produced as a solution with 1% of the content of active ingredients.. Polyethylene bottle accommodates 15 ml. In addition to the screwy plastic cover, the drum-dropper is attached, which gives us convenience when processing the affected areas of the mucous membrane.

1 The percentage solution has no color and pronounced smell, but in the processing process there is a bitter taste. The consistency is convenient for the treatment of foci - the viscous substance is well fixed on the mucous membrane. Candid in the solution is intended only for the treatment of the oral cavity.

pharmachologic effect

Clotrimazole in the composition treats fungal infections.

The active component of the drug (clotrimazole) is an imidazole derivative, which has a wide range of action in the treatment of fungal infections. The antimicotic effect is due to the ability to disrupt the synthesis of ergosterner, which is part of the membrane of mushroom cells.

As a result of such an intervention, there is a change in the structure of the cell and its properties, which leads to the destruction of microorganisms.

Clotrimazole has an impact on the following types of fungi:

dermatophytes;
yeast-like (Candida, Torulopsis Glabrata, Rhodotorula);
mold.

No less efficiently operates the active component of the causative agent determined by Pityriasis Versicolo and the eritresses causative agent.

The antifungal effect of the drug is noted in relation to staphylococci, streptococci, as well as pathogenic bacteria (Bacteroides, Gardnarella Vaginalis, Trichomonas Vaginalis).

When using a means on mucous membranes and soft tissues, there is a slight adsorption, but the depth of the penetration of the active substance is sufficient enough to effectively combat the fungus.

Instructions for use

Apply liquid candid should be strictly in the doses assigned to the doctor or specified in the instructions. It is not worth skipping processing, as well as combine two at once, increasing twice the amount of funds.

Dosage for adults and children

For processing the mouth of the child, 2-3 drops of the means are most often prescribed, which are applied with a cotton wand on the affected areas.

The candidate solution is applied using a piece of molding (cotton sticks) on the affected areas of soft tissues of the oral cavity (not on the whole mucousa!). One processing involves the use of 10-20 drops.

You need to repeat the procedure for adults 3-4 times a day, the therapeutic effect is noticeable on the 3-5th day after the start of use. If no improvement is noted during this period, the doctor makes an additional appointment, which provides a comprehensive approach to the elimination of the problem.

The dental treatment of focal zones on the mucous is desirable to carry out at the same time (after meals). If a positive result is noticeable in the first days after treatment, it is not worth discontinuous, the residual cells of the fungus can re-enter the active phase of development. The re-exposure to clotrimazole will be less effective, since microorganisms are purchased with respect to it sustainability. This complicates further treatment.

Children from 3 years old dosage and mode of application of a solution Candid appoints a doctor, based on the type of pathogen and the extensity of the lesion zone. More often a single rate for a child is 2-3 drops, applied on a cotton wand, which transports the remedy to the focus. Healthy pieces of mucosa need to be bypass. The processing is recommended no more than 3 times a day (after meals).

Important! For an hour after the procedure with the use of a solution, candida cannot be eaten.

Duration of treatment

With early diagnosis of fungal infection, Candid treatment rates a positive effect, but in any case there is a two-year application of the solution. The antifungal agent is used systemically, if you stop the processing of the affected areas of the mucous membrane earlier than the specified period, the fungus appears resistance to the active component of the drug, which reduces its pharmacological actions during re-use.

Stomatitis in a weak form of development does not require long-term treatment, so more often the doctor prescribes candidium in solution for use for a week.

Instructions for use for infants (newborns)

Before applying Candida for a newborn, be sure to consult your doctor.

Candid is prescribed to infants when the oral cavity is appeared on the mucous membrane. Such a defeat is caused by the development of fungus, so requires treatment. Otherwise, the focus will grow further, hitting the digestive organs, the field of genital organs.

With candidal stomatitis (thrush), the loss of appetite is noted, the baby becomes bellis and restless. To eliminate the problem with local treatments with a clotrimazole based antifungal agent.

With light stomatitis, the mucous girl is processed with candidium solution in the following order:

moisten a cotton disk in a weak solution of potassium permanganate and rub the mouth mucosa;
on a clean cotton disk or cotton wand to apply 3 drops of the drug and point movements to process the places of damage to the fungus (as an option to wind on a finger bandage and apply a working solution on it).

According to the instructions, the number of procedures per day is no more than 2 times. After 2-3 days, improvements will be visually noticeable, the damage zone will decrease. For the treatment of light shape of Stomatitis, we will need a week, and more complex cases provide for an integrated approach with an additional treatment with an alkaline solution (soda up to 5 times a day) and other antifungal agents. Increase the dose Candida or the number of day procedures is impossible. Treatment with extensive thrush is dragged to 10-14 days.

Contraindications

There is no significant restrictions on the use of Candid tools, however, before use, you should familiarize yourself with the composition to eliminate the allergic reaction to the components contained in it. Also the drug is contraindicated:

during pregnancy on the first trimester (active substances can have a negative impact on the development of the fetus);
during breastfeeding period.

The doctor's consultation needs to be aware of its existing allergies, its pathogens, pregnancy. The limitations of the first trimester of the fetus of the fetus may be accompanied by a complete refusal of adoption of Candida. Specialist, having studied analyzes and information about pregnancy, weighs all risks and threats from the use of Clotrimazole.

Side effects

Hives

Often, Candid does not give side effects. But with hypersensitivity to active substances of the drug may be observed:

redness of the oral mucosa;
hives;
the burning or tingling of the processed area.

If unpleasant symptoms are detected and the deterioration of the state from the further use of the solution is better abandoned. In such cases, the doctor resorts to the appointment of analogues or other forms of the candidate candidate.

The taste of bitterness in sensitive people can cause nausea, and even a vomit reflex. And when ingestion, the diarrhea and spasms in the abdominal cavity rarely arise inside with saliva. These factors do not render further treatment of a negative effect.

Extremely rarely after use Claims are observed:

rash on the skin;
outlet on the face, neck, language;
labored breathing;
dizziness;

These signs indicate an allergic reaction. Treatment in this case should be stopped and urgently consult a doctor.

Overdose

Increased dose Candida during processing does not have a negative impact on the condition of the mucous membrane, the human health does not represent. The percentage of suction funds in blood is minimal.

Compatibility with other medicines

Complex forms of the disease include comprehensive treatment. When appointing candidates in combination with the use of Nistatin and amphotericin, a decrease in the activity of Clotrimazole is noted.

Price

The cost of funds fluctuates within 280-397 rublesWhat is explained by the market prices of different regions of the country, the terms of suppliers and logistics companies. Order Antifungal solution as an option via the Internet, saving on average 50-70 rubles.