Panadol Extra Tablet Swiming Instructions for use. Panadol Extra Panadol (Panadol Extra) - "Panadol Extra will help bring down the temperature and reduce pain at home

Panadol Extra Refers to the category of combined means.

The medication has an analgesic, antipyretic and psychostimulating effect.

The complex effect of the drug is due to the content in its composition of paracetamol and caffeine.

Components will be stopped with pain syndrome and normalize the overall condition of the body.

Panadol Extra enters into a group of non-steroidal anti-inflammatory funds. You can use the drug when painful sensations of various genesis occur.

The medication has certain contraindications and age limitations. Before taking tablets, it is recommended to pay attention to the nuances of drug interaction and special instructions marked in the instructions.

Instructions for use

The instructions for Panadol Extra contains detailed information on the composition of the drug, the principle of operation on the body of its active ingredients, indications for use and the reception scheme.

In some items, contraindications and possible side effects are indicated. Additionally, the manufacturer explains the nuances of drug interaction of medication with other pharmaceutical agents. The instructions also describe the age limitations and special instructions that need to be considered before the start of therapy.

pharmachologic effect

The main pharmacological property of Panadol Extra lies in construction of painful syndrome of various origins. With coldic diseases, accompanied by an increase in body temperature, the drug affects the center of thermoregulation and produces an antipyretic effect.

You can use a medicine with sudden bounties or for the symptomatic treatment of progressive pathologies.

Pharmacological properties:

• analgesic effect;
• reduction of prostaglandin levels;
• relieving pain of different origin;
• increasing the level of paracetamol in the brain;
• improving the overall health of the body;
• elimination of excessive drowsiness;
• stimulation of the central nervous system;
• an increase in blood pressure (under hypotension);
• normalization of cardiac frequency;
• reducing the excitability of the thermal center.

Release form and composition

Panadol extra is available in the form of tablets in a solid shell and soluble (effervescent) tablets. In one package there may be one blister with 12 tablets in a solid shell or 6 strippers with two effervescent tablets (2 pcs. In one stripe).

Indications for use

Panadol Extra used to relieve the pain of moderate and moderate severity (With exacerbation of chronic pathologies, it is recommended to supplement the NSAB with other drugs).

The drug effectively eliminates the headache and reduces the symptoms of certain diseases. Medication can be used as an antipyretic agent in the treatment of sharp respiratory diseases.

Indications for use:

• manifestations of arthralgia;
• headache;
• migraine attacks;
• neuralgic manifestations;
• pain of rheumatic origin;
• muscle pain;
• algodismenorye.

Method of application and dosage

Panadol Extra is possible take short-term courses (To relieve a sudden attack of pain) or as part of the complex therapy of diseases accompanied by pain syndrome.

Application schemes and their nuances:

• one-time reception of tablets with a sudden bout of pain (1-2 tablets);
• three-day course of therapy with severe pain syndrome (one or two tablets every four hours);
• if the pain does not stop within three days, a doctor's advice is needed (in some cases the drug can be prescribed by courses to ten days);
• the daily dosage should not exceed eight pills (regardless of the form of release of the drug).

Interaction with other drugs

The active active ingredients from Panadol Extra can enhance or reduce the effectiveness of other pharmaceuticals. To reduce the negative impact on the liver, the drug is recommended to complement microsomal oxidation inhibitors (cimetidine). During therapy, medications cannot be taken with ethanol and caffeine content.

Other Nuances of Medicinal Interactions:

• Kolistramine reduces the absorption rate of paracetamol;
• when combined with tricyclic antidepressants and barbiturates, the risk of hepatotoxic manifestations appears;
• it is impossible to receive a medication simultaneously with other medicines based on paracetamol or caffeine;
• cumarine anticoagulants can provoke bleeding of various localization when combined with Panadal Extra;
• it is impossible to take medicine simultaneously with rifampicin, phenylbutazone and phenytio.

Video: "Unpacking of effervescent pandol extra tablets"

Side effects

In compliance with the dosages and the exclusion of contraindications, the risk of side symptoms as a result of the reception of Pananol Extra is practically excluded. Unwanted organism reactions may occur with increased sensitivity to paracetamol or caffeine. Side effects are manifested in the form of allergic rashes, the swelling of the mucous membranes or violations by the work of the internal systems.

Other side effects:

• signs of tachycardia;
• swelling quinque;
• thrombocytopenia;
• violations in the composition of blood;
• attacks of nausea or vomiting;
• harsh headaches;
• agranulocytosis;
• insomnia;
• leukopenia.

Overdose

Do you know that ...

Next fact

Exceeding Panadol Extra dosage creates risk of increased hepatotoxic effect. Possible nephrotoxic effect. With a single overdose, the patient needs to rinse the stomach and take funds from the Enterosorbent group.

The consequences of a regular disorders of the dosing regime are eliminated by symptomatic treatment (consultation with a doctor and a comprehensive examination).

Other consequences of overdose:

Contraindications

Panadol Extra it is forbidden to appoint children to fourteen years. The drug is not used during pregnancy and lactation. The risk of side symptoms is present when taking tablets during insomnia.

It is impossible to apply a medication to relieve pain patients with increased sensitivity to components from its composition. With elevated pressure, a prior consultation of the doctor is necessary.

Other contraindications:

• arterial hypertension;
• serious atherosclerotic pathologies;
• violations of blood coagulation;
• pronounced hepatic dysfunctions;
• progressive renal failure;
• hyperbilirubinemia of constitutional type;
• glaucoma.

During pregnancy and lactation

Pregnancy and the lactation period refer to the list of contraindications for receiving Panadol Extra. Active components from tablets can harm the fetus. When lactation, the use of the drug is permissible only under the condition of cessation of breastfeeding for a period of therapy.

special instructions

Impact on the ability to driving vehicles and control mechanisms

Panadol Extra has an impact on the central nervous system. In the occurrence of side symptoms, the speed of psychomotor reactions is broken. The presence of these states means compliance with caution in controlling complex mechanisms or the elimination of potentially hazardous activities (including driving a car).

Application in pediatrics

Panadol Extra is allowed to use from fourteen years. For patients younger age category, it is necessary to use drugs with appropriate marks.

With kidney dysfunctions

Progressive kidney pathologies are contraindications to use Panadol Extra. It is strictly forbidden to adopt the drug in renal failure.

With liver deviations

Pronounced hepatic dysfunctions are contraindications for use of Panadol Extra. Violations of this restriction may cause serious adverse symptoms.

Terms and Storage Terms

The shelf life of Panadol Extra is four years. Patches of tablets are indicated on the main and additional packages. When storing the drug, it is recommended to ensure the optimal temperature regime (not higher than 25 degrees) and exclude the impact of heat sources. Access children to drug should be limited.

Price

Conditions of vacation from pharmacies

Panadol Extra can be purchased in pharmacy items without a recipe.

The average price in Russia

The cost of one packaging of Panadol Extra in Russian pharmacies is approximately 120 rubles.

The average cost in Ukraine

Panadol Extra price in Ukrainian pharmacies averages 50-60 hryvnia.

Analogs

Replace Panadol extra paracetamol medicines or drugs with identical pharmacological properties.

With the intolerance of the active ingredients, the composition of the analogs must be paid to special attention.

Prices, application schemes, contraindications and age limitations of substitutes may differ.

Examples of analog:

• Salpadein FAST (120 rubles);
• Migrenol (150 rubles);
• Nooofen (from 120 rubles);
• Paracetamol (from 40 rubles);
• Effergangan (from 100 rubles).

Panadol Extra is a combined drug, which contains the most popular anti-inflammatory medicine - paracetamol and caffeine, which enhances the therapeutic effect of the main component.

Structure

Paracetamol - 500 mg. Paracetamol. It has analgesic and antipirective effects. The anesthetic effect is achieved due to the oppression of synthesizing processes prostograndinov , due to the enzyme inhibition Cyclooxygenase . Analgesic effect is due to paracetamol ability to influence pain impulses in the nervous system and influence the center of thermoregulation in the hypothalamus.

Caffeine - 64 mg. Caffeine. It has a psychostimulating effect. Caffeine eliminates the feeling of fatigue and drowsiness, enhances the effect of analgesics, increases mental performance and physical endurance.

Information about the preparation

• Trade name - Panadol Extra
• Combined drug that has an anesthetic and antipyretic effect.
• Form of release - tablets in the film shell.
• Where can one buy? Sold in each pharmacy, is released without a doctor's prescription.
• Manufacturer - GlaxosmithKline, Ireland.

Indications for the use of Panadol Ecstas

All readings are indicated in the instructions for Panadol Extra. They are duplicated on cardboard packaging of the drug:

How to drink Panadol Extra?

The method of application and dosage is indicated on the box:

Contraindications

special instructions

The duration of the preparation should not exceed three days. If during this time the symptoms did not disappear, you need to run to the doctor for advice.

Possible side effects

Panadol Extra in the treatment of ARVI and my personal impression of the drug

Unfortunately, the headmagnery pains for me are not uncommon. I have a sufficiently painful first days of the menstrual cycle, when without a reliable painkillers, it is difficult to stay in the ranks. Therefore, Panadol Extra is my chopstick. He repeatedly saved me and with dental pain, helped well with her back pain.

But most often Panadol and other analogies I use for the symptomatic treatment of ARVI. Of course, for the treatment of your chronic tonsillitis or hymorite, I use more powerful preparations, but Panadol and then helps to cope with pain.

Komarovsky believes that the purpose of paracetamol and its analogues is justified only under viral disease. In bacterial pathologies or aggravation of ARVI, these medicines will not help to quickly confuse the temperature:

With no one serious infection, it fails with a paracetamol to achieve a significant reduction in body temperature. That is why Paracetamol must always be in the house, because it helps parents to correctly assess the severity of the disease: if after taking the body temperature quickly decreased, it means that you can conclude with a high degree of probability that there is nothing terrible (more terrible than ORVI).

Paracetamol is a kind of marker of the severity of the disease. It helps to assess the severity of the situation:

And here if the effect of paracetamol is missing - here is the time to hinder and do not postpone into a long drawing appeal to the doctor.

This is a quotation of Komarovsky, I believe that, if you doubt a state of health, you should not postpone the visit to the doctor or at least pass the elementary blood tests.

The main thing is to understand - Panadol Extra is the symptomatic drug, it does not treat any disease. He simply removes the symptoms, reduces the temperature, facilitates pain and improves well-being. This medicine is not appointed according to the standard - for example, 1 tablet 3 times a day. It must be drunk only with severe negative symptoms.

Medical Use Instructions for Medicine

Panadol ® Extra

Tradename

Panadol ® Extra

International non-proprietary title

Dosage form

Tablets covered with film shell

Structure

One tablet contains

activey Substancesbut: paracetamol 500 mg,

caffeine 65 mg

excipients: starch premarital, starch corn, polyvidone (K-25), potassium sorbate, talc, stearinic acid, sodium croskarmellosis, water purified, sorbitol, sodium saccharin, sodium hydrocarbonate (especially thin bicarbonate), Vidamon K25, sodium lauryl sulfate, dimethicone, lemon acid Anhydrous, sodium carbonate anhydrous, purified water, hyprontellos (HPMC, 6 CPS), triacenetin.

Description

Capsyl shape tablets covered with a film shell of white color, with flat edges, marking in the form of a triangular logo and embossing "+" on one side and without labeling on the other side.

Pharmacological group

Antipyretics analgesics Others. Anilides. Paracetamol in combination with other drugs (excluding psycholeceptics)

ATH code N02BE51

Pharmacological properties

Pharmacokinetics

Paracetamol- Quickly and almost completely absorbed (96%) from the gastrointestinal tract. Paracetamol penetrates through the fetoplacentage barrier and stands out with breast milk in minor quantities. Studies found that paracetamol does not have a genotoxic and teratogenic effect. The maximum blood concentration is about 6 μg / ml, the time to achieve the maximum concentration of 10-60 minutes. Binding with plasma proteins in therapeutic concentrations is minimal. Paracetamol is metabolized in the liver, its large part enters the reaction of conjugation with glucuronic acid and sulfates to form inactive metabolites and is derived from urine as sulphate and glucuron conjugates. The period of semi-elimination (including the elderly) on average is 2.3 hours.

Caffeine - Quickly absorbed during oral administration, the maximum concentration in the blood plasma is achieved within one hour, the half-life is about 4.9 hours. 65-80% of the accepted caffeine is excreted in the form of 1-methylmoc acid and 1-methylxanthine.

Pharmacodynamics

Paracetamol - Analgesic Antipiretik. It has an anesthetic and antipyretic effect by suppressing the synthesis of prostaglandins in the hypothalamus. In this regard, the use of paracetamol is particularly appropriate in patients, for which the suppression of prostaglandin synthesis in peripheral tissues is undesirable, for example, if there is a history of gastrointestinal bleeding or in elderly patients.

Caffeinerefers to the group of alkaloids (methylxantines). It has psychostimulating and analeptic action. In combination with analgesics, in particular, with paracetamol, enhances its analgesic effect.

The drug does not affect water-salt exchange, because it does not affect the synthesis of prostaglandins in peripheral tissues.

Indications for use

Pain syndrome of light and moderate severity: Headache, migraine, toothaches, pain after the removal of the tooth or other dental interventions, pain in osteoarthritis, pain in muscles and joints, pain in the throat, painful menstruation.

Fevering syndrome: Increased temperature and pain with colds and influenza, as well as after vaccination.

Method of application and dose

Adults (including older) and children over 12 years old: Take an inside of 1-2 tablets every 4-6 hours, if necessary. Do not take more often than after 4 hours. Maximum single dose - 2 tablets. Do not take more than 8 tablets within 24 hours.

Do not exceed the specified dose.

Side effects

Rarely (<1/10,000)

Thrombocytopenia

Anaphylactic reactions

Skin reactions of hypersensitivity, including skin rash, angioedema edema, Stevens-Johnson syndrome

Bronchospasm in patients with increased sensitivity to acetylsalicylic acid and other NSAIDs

Violations of the liver function

Frequency unknown

Nervousness

Dizziness

Simultaneous reception of the drug with caffeine-containing products (for example, coffee, tea, caffean-containing drinks) can lead to a breakdown of sleep, anxiety, irritability, headaches, gastrointestinal disorders and rapid heartbeat.

It is necessary to stop taking the drug and immediately consult a doctor in the occurrence of the above reactions, as well as the appearance of peeling, ulcers in the oral cavity, difficulty breathing, hematoma, bleeding, or any other unwanted response to the drug.

Contraindications

Increased sensitivity to paracetamol or any other ingredient of the drug

Severe liver or kidney function

Arterial hypertension

Glaucoma

Sleep disturbance

Children's age up to 12 years

Pregnancy

Medicinal interactions

Paracetamol with admission for a long time enhances the effect of indirect anticoagulants (warfarin and other kumarins), which increases the risk of bleeding. The irregular reception of the drug does not have this effect.

special instructions

Before receiving the drug, you must consult with your doctor:

Patients taking warfarin or other drugs to reduce blood coagulation;

Patients with chronic liver or kidney diseases;

In case the headache becomes constant.

The use of paracetamol under states that reduce glutathione levels (for example, during sepsis) increases the risk of metabolic acidosis.

When a combination of the following symptoms appears:

Deep, rapid, difficult breathing

Poor well-being (nausea, vomiting)

Loss of appetite

you should consult a doctor.

Pregnancy and lactation period

The drug is not recommended for pregnancy in connection with the possible risk of spontaneous interruption of pregnancy with caffeine. Taking the drug during breastfeeding period should be avoided, as caffeine is distinguished with breast milk and can cause excitement from a child.

Features of the influence of the medicinal product on the ability to control the vehicle or potentially hazardous mechanisms

There are no restrictions on driving a car and working with mechanisms.

Overdose

Paracetamol

Symptoms: Nausea, vomiting, pain in the stomach, sweating, pallor of the skin. After 1-2 days, signs of liver damage are determined (soreness in the field of liver, increasing the activity of "liver" enzymes). In severe cases, liver failure, encephalopathy and comatose state develop.

Treatment:stop reception of the drug and immediately consult a doctor. It is recommended to wash the stomach and reception of enterosorbents (activated carbon, polyfepan). It is possible to use N-acetylcysteine \u200b\u200bor methionine.

Caffeine

Symptoms: Pain in the epigastric area, nausea, increased urination, tachycardia or arrhythmia, symptoms of stimulation of the central nervous system (insomnia, excitement, anxiety, increased excitability, nervous trembling, tremor and convulsions).

Treatment: Symptomatic therapy. No specific antidote. The use of β-adrenoreceptor antagonists can reduce the cardiotoxic effect.

With random overdose, immediately seek medical care, even with good health.

Panadol Extra (Panadol Extra)

Structure

1 Tablet covered with a shell, Panadol extra contains:
Paracetamol - 500mg;
Caffeine - 65mg;
Excipients.

1 drop covered with shell, Panadol extra contains:
Paracetamol - 500mg;
Caffeine - 65mg;
Excipients.

1 Panadol Extra Salub tablet contains:
Paracetamol - 500mg;
Caffeine - 65mg;
Excipients.

pharmachologic effect

Panadol Extra is a combined drug containing paracetamol and caffeine. The drug has an analgesic and antipyretic effect. Paracetamol The drug of a group of nonsteroidal anti-inflammatory drugs, contributes to a decrease in the level of prostaglandins in the central nervous system due to the oppression of the cyclooxygenase enzyme. Caffeine helps to strengthen paracetamol pharmacological effects.
Paracetamol after oral administration is well absorbed in the digestive tract, the peak of plasma concentration is marked after 0.5-2 hours after the reception. Metabolized in the liver. The half-life reaches from 1 to 4 hours, is removed mainly with the urine in the form of metabolites.

Indications for use

The drug is used to treat patients with painful and moderate intensity of different etiology, including:
Headache, migreen pain and migraine attacks.
Muscular pain, neuralgia, arthralgia, rheumatic pain.
Algodismenoria.
In addition, the drug can be used as an antipyretic remedy for influenza and ARVI.

Mode of application

The drug is taken orally. The tablets covered with a shell, and killets covered with a shell, it is recommended to swallow the whole, not chewing and without grinding, drinking with enough water. Panadol Extra Salub Tablets Before use, it is recommended to dissolve in a glass of water. The duration of the treatment and dose of the drug determines the attending physician individually for each patient.
Adults and adolescents over the age of 12 are usually prescribed to 500-1000 mg of the drug (2 tablets or 2 killets or 2 pills of effervescent) 3-4 times a day with an interval of at least 4 hours.
The maximum daily dose of the drug is 4000mg (8 tablets).
Reception of the drug for more than 3 days in a row is possible only by appointing the attending physician.
During the treatment period, Panadol Extra should not consume a large number of drinks containing caffeine.

Side effects

The drug is usually well tolerated by patients, in some cases the development of such side effects was noted:
From the digestive tract: nausea, vomiting, pain in the epigastric area. In addition, a change in the activity of hepatic enzymes and toxic liver damage is possible.
From the side of the blood formation system: thrombocytopenia, pancytopenia, anemia, including hemolytic, sulfathemoglobinemia and methemoglobinemia.
On the part of the central nervous system: violation of sleep and wake mode, increased irritability, dizziness.
From the side of the cardiovascular system: arterial hypertension, tahiaritium.
Allergic reactions: skin rash, itching, urticaria, multiform exudative erythema, swelling of quinque, Layella syndrome, anaphylactic shock.
Others: bronchospasm, hypoglycemia, hypoglycemic coma.

Contraindications

Increased individual sensitivity to the components of the drug.
Heavy disorders of the kidney and / or liver function, congenital hyperbilirubinemia, glucose-6-phosphate dehydrogenase deficit.
The drug is not prescribed by patients suffering from alcoholism, violations of the function of the blood formation system (severe anemia, leukopenia), thrombophlebitis, thrombosis, atherosclerosis and arterial hypertension.
The drug is not used for the treatment of patients suffering from insomnia, glaucoma, including closedian glaucoma, epilepsy, hyperthyroidism, heart conduction disorder, decompensated heart failure, CHD, prostate hypertrophy, diabetes and sharp pancreatitis.
The drug should not be prescribed to the elderly patients and patients who have a tendency to spasm vessels.
The drug is contraindicated to use during pregnancy and lactation, as well as children aged 12 years.
The drug should be cautious to prescribe patients with liver disease and / or kidney.

Pregnancy

The use of the drug during pregnancy is possible only on life testimony.
If necessary, the drug during lactation should be resolved about the time interruption of breastfeeding.

Medicinal interaction

The simultaneous use of the drug with monoamino oxidase inhibitors, tricyclic antidepressants and beta-adrenoreceptor blockers, is contraindicated. A break in the treatment between the methods of drugs of the monoaminoxidase inhibitors and the drug Panadol Extra should be at least 14 days.
The absorption velocity of paracetamol increases with its simultaneous use with metoclopramide and home, while simultaneously use with cholestyramine - decreases.
With the combined use of the drug with warfarin and other kumarine anticoagulants, the risk of bleeding is increased.
Barbiturates weaken the antipiretic effect of paracetamol when combined.
Inductors of microsomal enzymes, hepatotoxic preparations and isoniazide increase the toxic effect of paracetamol on the liver.
With compulsive application, the drug reduces the effectiveness of diuretics.

The simultaneous use of drug with drugs containing ethyl alcohol, as well as alcoholic beverages, is contraindicated.
Caffeine with combined use increases the efficiency of alpha and beta-adreminimetics, xanthine and drugs that stimulate the central nervous system.
With the simultaneous use of cimetidine, oral contraceptives and isoniazid, an increase in caffeine efficiency is noted.
Caffeine with combined use reduces the effectiveness of drugs that depress the central nervous system.
Caffeine increases the content of lithium in the blood, enhances the therapeutic effect of thyrotropic drugs and improves ergotamine absorption in the gastrointestinal tract.

Overdose

Under the overdose of the drug, it is possible to develop the nephrotoxic and hepatotoxic effect of the drug, as well as the development of violations by the blood formation system (anemia, thrombocytopenia, pancytopenia, leukopenia, neutropenia, agranulocytosis) and the central nervous system (increased excitability, dizziness, violation of sleep and wakefulness, tremor) . In addition, the development of tachyarhythmias, seizures, palls of skin, vomiting, hepathonecosis, glucose metabolic disorders and metabolic acidosis is possible.
In case of overdose, the stomach washing, the reception of enterosorbents and the conduct of symptomatic therapy is shown. In case of severe overdose, the intravenous administration of N-acetylcysteine \u200b\u200band oral administration of methionine is shown (if the patient has no vomiting). In the case of developing seizures, diazepams are used.
Description of the drug " Panadol Extra"This page is a simplified and supplemented version of the official instructions for use. Before the acquisition or use of the drug, you must consult a doctor and familiarize yourself with the annotation approved by the manufacturer.
Information about the preparation is provided solely with an informational purpose and should not be used as a guide to self-medication. Only a doctor may decide on the appointment of the drug, as well as determine the doses and methods for its use.

Latin name:Panadol Extra
ATH code: N02BE51
Active substance: Paracetamol and caffeine
Manufacturer:
Pharmacy vacation condition: Without recipe

Panadol Extra is a drug with a combined composition, possesses painkillers.

Indications for use

The drug is used to relieve pain of moderate and medium degree of severity that develop on the background:

• Migraine
• Muscular and headaches
• Algodismenoria
• Neuralgia
• Pain of rheumatic nature
• Artralgia.

Panadol Extra can be used to remove sharp symptoms for influenza, ORVI, colds.

Structure

In one tablet of an anesthetic drug contains two active ingredients represented by paracetamol and caffeine, their dosage is 500 mg and 65 mg, respectively.
As additional components are used:

• Acid stearinovaya
• Potassium Sorbat
• Purified water
• Talc
• Polyvidon
• Triazhetin
• Croskarmellosis sodium
• Starch premaritalized
• Hydroxypropylmethylcellulose.

Medical properties

Therapeutic effect of the drug is due to the special properties of each of the active ingredients.
Caffeine has a stimulating effect on the CNS, which is associated with the impact on the psychomotor centers of the brain. This substance relieves the drowsiness, the feeling of strong fatigue and, along with this, contributes to the increase in the action of analgizing components. Caffeine is able to improve performance (both mental and physical).
Paracetamol manifests analgizing properties, has an antipiretic effect. The anesthetic effect is achieved due to the inhibition of the synthesis of special substances (prostaglandins), such an effect on the body is due to the inhibition of cyclooxygenase enzymes. In addition, paracetamol has an impact on the process of conducting a pain pulse in the NA, affects thermoregulation by direct influence on certain sections of the hypothalamus.
After oral administration of the tablets, a rather high degree of paracetamol absorption in the gastrointestinal tract is observed. After 30-90 minutes. In the blood, its highest concentration is found. Metabolic processes proceed in liver cells, the removal of metabolites is carried out by the kidneys.

Form release

Price from 42 to 161 rubles.

Panadol Extra is available in the form of conventional and effervescent of white-colored tablets without visible enclosures. Inside the package can post 10 ordinary tabs. or 12 epipherable tab.

Panadol Extra: Instructions for use

Panadol extra (tablets) is intended solely for oral administration. The standard treatment diagram of pain syndrome involves receiving 1-2 tab. Three times or four days per day. At the same time, the minimum interval between the drug intake should not be less than 4 hours. At a time you can drink no more than 2 tabs. The highest daily dosage of Panadol Extra should not exceed 8 tab.
As an analgizing agent, taking pandal and caffeine tablets is permitted no more than 5 days, use as a drug-anti-purpose - no more than 3 days. If necessary, the doctor can extend the appointed course of treatment.
If, after a standard course of treatment, there is no improvement in the patient's condition, you will need to consult a doctor for advice.
In the absence of expected positive dynamics in the treatment of pain syndrome, a doctor is required.

Application during pregnancy and gv

Receiving an anesthetic drug during pregnancy is possible in the presence of life testimony.
If there is a need to receive Panadol Extra at HB, it is worth completing breastfeeding.

Contraindications

Before starting the reception of ordinary and effervescent pills based on paracetamol and caffeine, it is worth familiar with the range of contraindications:

• Atherosclerotic changes
• Pregnancy, gv
• Violations in the blood formation system
• Signs of individual sensitivity
• Glaucoma
• Pathology of the functioning of the renal system and liver
• Insomnia
• Children's age (child up to 14 years old)
• Elevated hell
• Hyperbilirubiney
• The deficiency in the body of glucose-6-phosphate dehydrogenase caused by violations at the genetic level.

Precautions

It is not recommended to receive increased drug dosages without coordination with the doctor.
It is not desirable to use tea and caffeine-containing drinks in large quantities, there is a high risk of developing tachycardia, heart rate disorders and insomnia. Against the background, it can manifest nervous excitement.
Patients suffering from alcoholism, the drug is prescribed with caution.
Cross drug interactions
With the simultaneous intake of indirect anticoagulants, there is an increase in their impact on the body, the risk of opening bleeding increases.
The probability of occurrence of hepatotoxic influence increases with the use of inductors of microsomal oxyments in the liver (barbiturates, rifampicin, antidepressants of the tricyclic group, phenylbutazone, as well as phenytoin and ethanol).
The risk of developing negative impact on the liver is reduced by taking cimetidine or other drug-oxidation inhibitors.
Paracetamol affects the process of removal of chlorampheniol (rises in 5 p.).
Caffeine accelerates ergotamine absorption. When taking alcoholic beverages there is a high risk of developing liver pathologies and acute pancreatitis.
With a combined reception with a skewer, a decrease in paracetamol absorption rate is observed. The reverse reaction is diagnosed when receiving a domperidone or metoclopramid.
The medicinal effect of the medication is reduced by applying uricosuric drugs.

Side effects

When taking caffeine and paracetamol tablets, a number of side effects can develop, include:

• Insomnia
• Methemoglobiney
• Summer itching, rash
• Allergy, including swelling of Qink
• Blood coagulation disorders
• Lakeing
• Change cardiac rhythm (tachycardia)
• Lakeing
• Agranulocytosis.

With long-term method of medication, the likelihood of nephrotic, as well as hepatotoxic lesions increases. It is necessary to carry out regular control over the main blood indicators. If the listed reactions occur, it will be necessary to complete the reception of the tablets and contact the specialist.

Overdose

When receiving, doses of the drug may occur:

• Tremor
• Excessive nervous excitability
• Strong dizziness
• Violation of sleep quality.

Along with this, adverse reactions from the blood formation system and other reactions are not excluded:

• Violation of metabolic processes, and in particular glucose metabolism
• Violation of the activities of the CSS.
• Development of convulsion
• Pallor skin
• The emergence of metabolic acidosis
• Hepathonecosis.

When such symptoms appear, the procedure for washing the gastrointestinal tract, carry out the reception of drug-enterosorbents. Persons with severe signs of overdose are introduced in / in N-acetylcysteine, the reception of methionine is shown. To stop the appearance of a convulsive syndrome will help diazepam.

Storage conditions and shelf life

Panadol Extra storage should be carried out at a temperature not exceeding 15-25 s, the shelf life of this drug is 4 years.

Analogs

Glasosmitklein SK, United Kingdom

Price from 71 to 319 rubles.

Copadein refers to the number of highly efficient painkillers, is assigned to relieve painful sensations of various etiology. The active components of Salpadein are paracetamol, caffeine, as well as codeine. A drug is produced in the form of capsules, conventional and soluble tablets.

Pros:

• Quickly stops moderate and weakly expressed pain syndrome
• Several dosage forms
• It has antipyretic properties.

Minuses:

• Not prescribed to children under 12 years
• Recommended by prescription
• It is not recommended to take with epilepsy.